Targeting neuroinflammation in Alzheimer’s disease
نویسندگان
چکیده
منابع مشابه
Targeting neuroinflammation in Alzheimer’s disease
Almost 47 million people suffer from dementia worldwide, with an estimated new case diagnosed every 3.2 seconds. Alzheimer's disease (AD) accounts for approximately 60%-80% of all dementia cases. Given this evidence, it is clear dementia represents one of the greatest global public health challenges. Currently used drugs alleviate the symptoms of AD but do not treat the underlying causes of dem...
متن کاملTargeting Neuroinflammation to Treat Alzheimer’s Disease
Over the past few decades, research on Alzheimer's disease (AD) has focused on pathomechanisms linked to two of the major pathological hallmarks of extracellular deposition of beta-amyloid peptides and intra-neuronal formation of neurofibrils. Recently, a third disease component, the neuroinflammatory reaction mediated by cerebral innate immune cells, has entered the spotlight, prompted by find...
متن کاملTargeting neuroinflammation in the treatment and prevention of Alzheimer's disease
hyperphosphorylation and reduces memory loss. Thus, the emerging role of peripheral leukocytes in the pathogenesis of AD opens new avenues of investigation and may lead to the identification of new therapeutic approaches. This review summarizes our current understanding of the roles of vascular inflammation and circulating leukocytes in AD, focusing on recently discovered neuroinflammation mech...
متن کاملP 133: Neuroinflammation in Alzheimer ’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common form of dementia. Almost 47 million people suffer from dementia worldwide. AD accounts for approximately 60%–80% of all dementia cases. Three major pathologies characterize the disease: senile plaques, neurofibrillary tangles and inflammation. We review the literature on events contributing to the inflammat...
متن کاملNeuroinflammation in Alzheimer’s disease
Amyloid-β plaques and neurofibrillary tangles are the main neuropathological hallmarks in Alzheimer's disease (AD), the most common cause of dementia in the elderly. However, it has become increasingly apparent that neuroinflammation plays a significant role in the pathophysiology of AD. This review summarizes the current status of neuroinflammation research related to AD, focusing on the conne...
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ژورنال
عنوان ژورنال: Journal of Inflammation Research
سال: 2016
ISSN: 1178-7031
DOI: 10.2147/jir.s86958